如何运用磁场实现基因治疗？
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如何运用磁场实现基因治疗？
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這個在國外已經(jīng)有了報道：Kamihiraandhisteamconnectedafewgenestothispromoter.Onecodesfortumornecrosisfactor-α(TNF-α),aproteinthatinducescelldeath.Anothergenecodesforaproteinthatactivatesasecondelementinthecircuit.ThiselementkeepstranscriptionofTNF-αgoinglongaftertheheatstimulusisgone.Soafterapulseofexternalheat,apositivefeedbackloopturnsontocontinuouslyproducethecell-killingprotein.Totestthenanoparticle-genecircuitcombination,theresearchersinsertedthepromoterandgenesintohumanlungcancercells.TheyencasedtheDNAinsideliposomesthatfusewiththecells’membranesandreleasethegeneticinformationintothecell,whereitcanfindthecell’stranscriptionmachinery.Thentheyaddedmagnetitenanoparticlescoatedinlipids,whichalsoslippedinsidethecells.Whentheresearchersappliedanalternatingmagneticfieldfor30minutes,thecellswarmedto43°C,and90%ofthemdied.Heatfromthenanoparticlesalonealsokilledthecells,butnotaseffectivelyaswhentheywerecombinedwiththeheat-triggeredgenecircuit.Infact,whentheteamexaminedcellscontainingthenanoparticlesandaplasmidwithoutanyofthetherapeuticgenesfourdayslater,only60%ofthecellsexposedtothemagneticfieldweredead.Theresearchersalsotestedtheirmethodinmicewithtumorsgrownfrominjectedhumanlungcancercells.Theyalsoinjectedthegene-containingliposomesandmagneticparticlesintothetumorsite.Someanimalswereexposedtoanalternatingmagneticfieldfor30minutes;othermicewerenot.After30days,miceplacedinthemagneticfieldhadtumorsthatwerejust8%ofthevolumeofthoseinunexposedmice.http://cen.acs.org/articles/91 ... .html
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