靶向抑制性協同受體PD-1和CTLA-4的檢查點免疫療法徹底改變了癌癥治療，而LAG-3作為新一代發現的抑制性檢查點，有望成為腫瘤治療中J具前景的靶點。

艾美捷ProSci?LAG-3?重組蛋白的化學性質：

英文名稱：LAG-3 Recombinant Protein

cat#：PSI-90-241

規格：50ug

來源宿主：CHO?細胞

溶解建議：開蓋前，先離心。建議按說明書中要求的方式進行溶解和使用。

保存建議：Stable for at least 6 months after receipt when stored at -20?C.

物種：人類

來源物種：人體細胞

重組蛋白序列：Leu23-Gly434

融合標簽：C-6?his標簽

艾美捷ProSci?LAG-3 重組蛋白可以應用于已測試驗證過的應用類型。

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Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Specications：

Species Human, Monkey, Mouse

Source Species CHO cells

Fusion Tag Fc Tag

Biological Activity

Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic

cells.

Properties：

Purity

>99% (SDS-PAGE).<br><br> Endotoxin level is less than 0.1EU/?μg puried protein (LAL test;

Lonza).

Physical State Liquid

Buer In PBS.

Concentration 0.5 mg/ml

Storage Conditions Stable for at least 6 months after receipt when stored at -20°C.

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